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Encouragingly, this intervention yielded a weight loss of 15.1%

JAMA 289, 187193

X., Tani, T., & Akao, T

However, the sharp demand for these products and the lack of FDA approval of compounded GLP-1 is raising concerns about the safety, effectiveness, and consistency of these medications, which have grown popular for weight loss

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Berberine demonstrates DPP-4 inhibitory activity in cell culture and animal studies, potentially extending the half-life of naturally produced GLP-1